![]() A doctor may suggest taking a pill daily or using a skin patch twice weekly. The treatment can improve menopause symptoms, such as insomnia and hot flashes, as well as bone loss.ĮRT can come as a pill or skin patch. ERT involves taking artificial estrogen to increase estrogen levels in the body.ĭoctors may recommend ERT to people who have gone through menopause or had their ovaries removed. Some people use estrogen replacement therapy (ERT) to prevent or reverse osteoporosis. As people age, their levels of estrogen and sema3A deplete, which leaves the bones unable to maintain their structure. Sema3A protein: There may be a relationship between estrogen and the sema3A protein in osteocytes.Oxidative stress: An imbalance between free radicals and antioxidants can cause oxidative stress.Effects on bone cells: Estrogen affects bone cells, including osteocytes, osteoblasts, and osteoclasts. ![]() The immune system: Scientists think that estrogen affects bone homeostasis by regulating the immune system.Low estrogen levels affect how these cells function, making them produce too little new bone and not properly maintain bone structure.Įxperts do not understand exactly how estrogen affects bone, but they believe that the complex relationship between the two involves: They contain osteocytes, which are special cells that maintain this matrix.Įstrogen influences osteocytes, as well as other cells such as osteoblasts and osteoclasts. Bones are made up of a matrix of proteins and minerals, making them both strong and flexible.
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